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A 2025 analysis in the Journal of Clinical Oncology found that post-approval oncology clinical trial initiations for small molecules declined relative to biologics in the two years following IRA enactment, controlling for pipeline composition at the time of the laws passage

Lichtenberg D, Ragimova S, Peled Y, Halpern Z

BPC-157 is a carefully synthesized pentadecapeptide with specific molecular characteristics that defines its research applications

24 These modular structures allow for precise tuning of polarity and charge, offering a level of stability that can be patented as a new formulation, thereby granting the sponsor their own exclusivity